The region was named after Ioun.
Bam. Where's my No-Prize?
Except that Ioun didn't exist before 4E.
As for the elimination of the Blood War, I remember reading somewhere that WotC's primary objectives with 4E was to
A. bring new blood to D&D rather than appease old fans (as the new blood is far more likely to buy the books than the old fans, many of who now have jobs and family to worry about)
and
B. Corner the casual P&P gamer market.
Unfortunately, the casual P&P gamers do not care for the Blood War OR the Great Wheel, because they find the idea of several different heavens and hells to be both too complex and pointless.
As I mentioned before, a LOT of the gamers out there don't care for the 1-3x D&D fluff because they prefer to simply have a single heaven, a single hell, a single "team" of celestials, and a single "team" of fiends; they find the Blood War and in-fighting between various celestial and fiendish groups to bee too complicated, confusing, and pointless (and MANY found the yugoloths, eladrins, guardinals, archons and ALL the elemental planes to be boring and pointless, sadly.
I know, it's blasphemy to us on this site, but that's how a lot of people feel. They find the simplistic and one-sided 4E cosmology and fluff to be far more refreshing, though they don't like it, either, but at least they don't have to do as much work on the cosmology and monster types to make the setting they want.)
The casual gamer thing is also the reason why they're trying to simplify EVERYTHING so damn much (and I think they've gone way too far with Essentials, though I fear that were it not for WotC's confusion over what they're aiming to create with Essentials and their insidious plan to make it so that you have to purchase all 10 books to have a complete set of game rules, the Essentials would likely be incredibly popular, because people just plain suck. THe fact that the Madden series is so damn popular is proof of this. We have idiots out there who buy the current year's release of the game which has NO DIFFERENCES WHATSOEVER ASIDE FROM AN UPDATED ATHLETE ROSTER, something which should damn well be downloadable on EA's site for free as a patch. Oh, and don't get me *and everyone else in this topic* started on the crap that passes as a best seller in music, these days. I mean, there are good, quality songs in every genre, so why is it that the year's best hit singles are almost invariably the Mcmusic of the genre? WHY?!?!?!?!? Moving on).
A major complaint new gamers have had since the 80's about both AD&D and 3x is that they're far too complicated (especially 3x), that there's far too much bookwork, that there's far too much work for the DM to craft a session (esp. in 1E and 2E). So apparently, one of the major appeals of 4E is that it's exponentially easier to DM, and that the powers system makes it easier for the players to keep track of how much and how long of each spell/what have you they have left for the day/etc. (though honestly, I don't have any complaints about the Powers system mechanics in 4E)
The region was named after Ioun.
Bam. Where's my No-Prize?