I could have sworn this came up a couple years ago, but couldn't find the archived posts for it so thought I'd bring it up again.
Has anyone considered running Planescape with an anime system or theme? Considering the content of many anime - demons, magic, other planes/realities, the bizarre - one could easily see how the setting would mesh with the genre. On the other hand Planescape is so huge it is rarely designed to revolve around personal stories, which Anime places a great deal of focus on. (sure rpgs focus on personal stories, but in anime those stories tend to be more important than the setting or events surrounding the characters)
At any rate, pretty tired at the moment, but thought I'd throw the idea out there to see what others thought; if nothing else, generate a little more discussion.
Metamorphosis is designed to focus on the characters as much as the overarching plot. It's not running Planescape in the traditional sense but I think of myself as a DM sometimes. The intent of the comic, though, is to emphasize the characters' stories and put them within the Planescape framework. I'm not specifically taking an "anime" approach but I am hoping to put the characters first. Admittedly my storytelling approach and preferences have been influenced by character-driven ideas in anime storytelling
Game-systems, I've been toying with the idea of Planescape using Green Ronin's Mutants and Masterminds rules. Though it's not exactly an anime system like BESM, it's got a lot of good support for anime-style gaming. It also has at least one anime supplement (Mecha and Manga or something like that), so the developers are aware of the potential there.
http://kaitou-kage.deviantart.com/ -- My deviantART gallery
http://www.planescapemetamorphosis.com/ -- Planescape: Metamorphosis, a Planescape webcomic in the works