My version of Ortho has a heavy East/West dichotomy, and also a mention of a Southern continent, so I think either the second one down or the second one from the bottom works best. The second one down looks the easiest for a single civilization to conquer.
Sources:
Factol's Manifesto (primary source)
Planewalker's Handbook, page 33. Not really anything here that isn't in the Factol's Manifesto.
Tales From the Infinite Staircase, page 75. Description of the Riven, exiles from Ortho now living in the city of Blurophil in the Elemental Plane of Air.
Something I wrote on Ortho on these boards
Something I wrote on Ortho on the "...Unless Infinity" site
Rich Gant's description of Ortho's solar system
Zach Shuford on the Harmonium after the war
I really like the second one down because you could have a Central continent with East and West continents too. Could add more flavor to the world by having three different Continents with different cultures on them. Who knows?