I'm posting some minor questions here. It's stuff that's probably too small to need is own topic. Feel free to add your own.
Do portal keys disappear when used?
Is there an actual difference between planars and primes, besides their different places of origin?
Are the faction's world-views primarily centered on Sigil? Or do the Mercykillers, for example, depend on the Harmonium and the Fraternity of Order to enforce justice on other planes as well?
I'll try and partially answer some of those:
Depends on the portal. Some portal keys are consumed when they are used, others are not. If it's not mentioned in the description of the portal then it's the DM's call, and really depends on how hard you want to make it to use a particular Portal.
Not sure on #2, but I know that those born on the planes can see portals whereas those born of the Prime cannot. Apart from general planar knowledge I wouldn't imagine there would be great differences between planars and primes of any given race.