Your PS campaigns probably don't involve much travel to published Prime worlds, but I'm guessing you have opinions on the subject. What I'm asking is how many of the TSR/WotC published settings actually work within traditional PS cosmology?
Eberron certainly doesn't, and I believe FR has a couple significant differences. Greyhawk, Dragonlance and Ravenloft fit perfectly, but I'm not a setting aficionado so I don't know about the others. (Birthright, Dark Sun, Al Quidam, I'm sure there are more.)
Also, what do you do with the ones that don't fit? Ignore them, change them, or just keep squinting until the details don't matter?
Since the topic is prime worlds, would it be fair to call it the Planescape/Spelljammer cosmology? Those two systems explicitly link Oerth (Greyhawk), Krynn (Dragonlance), and Toril (Forgotten Realms). Al-Qadim exists on Toril and it seems safe to say that Athas (Dark Sun) is out there but simply cut off from everything else.
Search these forums for Eberron and you'll find quite a bit of impassioned discussion on both sides of the matter.