Planescape as Life's Symbiote
I think one of the advantages to PS is akin to that of Mage the Ascension, that it integrates life into the game. This is RPG as literature, as music, as a hungry thing that takes your observations and experiences and makes you wonder how they fit into the great puzzle piece of your cosmology, your characters, your game.
How many other RPGs can attempt to lay claim to your thoughts in such a manner, bees touching the flowers of your mind be they entertainment or economics, mathematics or art history? Sociology and psychology make you think on how fiends and angels live and love, business classes make you wonder about trade between infinite universes of belief.
This is the greatness of PS, this incredible inclusiveness to the rest of your existence. I never used to dream in campaign setting...